Dr. Mushtaq Loan
Funded By: - Kuwait Foundation for Advancement of Science (KFAS)
Summary: - The latter research discipline is a challenging field of the interface between particle physics and oncology with an emphasis on radiation-induced death rate in tumour cells using hadron radiations. Hadron therapy is mostly used for treating tumours that are located close to vital organs that would be unacceptably damaged by x-rays, or in oncology, where quality of life and late side effects are a major concern. The use of the hadrons and light ions allow obtaining a high relative biological effectiveness (RBE), which makes hadrons particularly suitable to treat cancers that are resistant to conventional photon therapy. We develop mechanistic models of DNA repair and cellular survival following radiation-induced DNA damage. This allows predicting the radiobiological effectiveness of hadrons (protons, alpha particle) and light ions and relationship between physical parameters of radiation and probability of cell survival more accurately for clinical treatment protocol. Numerical simulations, incorporating the combined effects of biological processes such as the tumour oxygenation, cellular multiplication, and mutation and physical processes of particle LET and hadron spices, are performed on a stochastic models based on Monte Carlo damage simulation process to investigate the formation and evaluation of isolated and multiple DNA damage and cellular survival by light ionizing radiation in a colony of tumour cells.
